Iron, Ferritin and Energy: Why Low Iron Leaves You Exhausted

Published: June 2025

Low iron can lead to fatigue, brain fog, and poor oxygenation. Learn how biomarkers like ferritin, iron and RDW affect energy — and how diet can fix it.

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If you feel constantly tired, foggy, or out of breath with light exertion, low iron could be to blame. Iron is essential for oxygen transport, red blood cell production, and brain function. Deficiency often shows up in biomarkers like ferritin, serum iron, transferrin saturation, and RDW (red cell size variation).

Iron deficiency anemia leads to smaller, less efficient red blood cells and a high RDW — often above 17% [PubMed]. Meanwhile, the World Health Organization confirms that low iron impairs physical performance, focus, and productivity [WHO].

But it’s not just about too little — excess iron (ferritin >300 ng/mL) may indicate inflammation or iron overload, which can cause oxidative stress and metabolic strain.

Balancing your iron status is key for lasting energy and mental clarity.

💡 Practical Takeaways:

Test for these Biomarkers:

Ferritin, Serum Iron, TIBC, Transferrin Saturation, Haemoglobin, Haematocrit, RDW, MCV, Red Blood Cell Count