Specialist marker · Autoimmune
An anti-CCP blood test looks for antibodies against cyclic citrullinated peptides, the most specific blood marker for rheumatoid arthritis. A positive result points strongly to RA and can appear years before joints become swollen. Anti-CCP is included in TrueVitals Signature (£799), read alongside rheumatoid factor, ESR, hs-CRP and ANA.
In rheumatoid arthritis the immune system makes antibodies against proteins that have been chemically altered (citrullinated) in inflamed joints. Anti-CCP detects those antibodies.
It is far more specific than rheumatoid factor: a positive anti-CCP is rarely seen in people who do not have, or will not go on to develop, RA. A positive result is also linked to a more active, more erosive course, which is why early treatment matters.
A negative result does not rule RA out: about a third of people with RA never make anti-CCP (seronegative RA), and the diagnosis is clinical. A positive result with joint symptoms needs a GP and usually a rheumatology referral. Your report reads anti-CCP with rheumatoid factor, ESR, hs-CRP and ANA to show whether there is active inflammation as well as the antibody.
| Option | Includes it | Price | What else you get |
|---|---|---|---|
| TrueVitals Signature | Yes | £799 incl. draw | Anti-CCP with rheumatoid factor, ESR, hs-CRP, ANA, complement C3 and C4 among 230 biomarkers. Clinician-reviewed report. |
| TrueVitals Ultimate | No | £399 incl. clinic draw | Rheumatoid factor, ESR and hs-CRP, but not anti-CCP. |
| NHS GP | On request | Free if clinically indicated | Usually requested when RA is suspected, often alongside a rheumatology referral. |
TrueVitals prices checked 5 November 2026. Every TrueVitals report is clinician-reviewed. Pay in instalments with Klarna or Clearpay. Signature is drawn at one of 70 Randox Health clinics; Ultimate at one of 103 partner clinics or with a home visit.
When to see your GP now: swollen, warm or stiff joints, particularly in the small joints of the hands or feet, should be seen promptly whatever any test shows. Early treatment of RA protects the joints, so do not wait for a private result.
A private panel is a good way to get a baseline, understand a result in context and track it over time. It does not replace your GP for symptoms, and anything that needs follow-up is flagged in plain words in your report.
No. Ultimate includes rheumatoid factor, ESR and hs-CRP. Anti-CCP is included in Signature.
Yes. About a third of people with RA test negative for anti-CCP. The diagnosis is made from symptoms, examination and imaging as well as blood tests.
Yes. It can appear years before joints become swollen. A positive result without symptoms is worth discussing with your GP so any new joint symptoms are acted on quickly.
Labs report it against their own cut-off. A result below the cut-off is negative; a strongly positive result is more meaningful than a weakly positive one.
Not for anti-CCP itself, but Signature includes fasting markers, so an overnight fast with water only is advised.
How this page was written: by James Smillie, founder of TrueVitals, reviewed by the TrueVitals clinical review team, using NHS and laboratory reference sources. Ranges are typical values; your report uses your lab's own ranges. TrueVitals sells the panels named on this page, so we have stated plainly what this test cannot do. Last updated 5 November 2026.
Signature: 230 biomarkers including anti-CCP, rheumatoid factor and ANA, £799 including the draw. Clinician-reviewed report.
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