The gold standard

Signature
Panel

Everything in Ultimate, plus the tests a specialist would order. 230 biomarkers processed by Randox Health, physical measurements at your appointment, PhenoAge and your TrueScore. The depth of a £2,000 private health assessment, for £799.

Rated Excellent on Trustpilot
£799Clinic appointment included
Klarna3 interest-free payments of £266.33
230 biomarkers for men · 229 for women · report within 12 working days
"Absolutely excellent life changing results." Verified Signature review, September 2026
Book Signature, £799
  • All 140 Ultimate markers
  • 90 markers on no other panel, 40+ specialist assays
  • Physical measurements included
  • PhenoAge and TrueScore
  • No findings, no fee
  • Clinician review before release
TrueVitals Signature Panel premium collection kit in black and gold with scales, blood pressure monitor, tape measure and the TrueVitals report on a phone
TrueVitals Signature Panel report overview with PhenoAge and TrueScore
TrueVitals report body map showing which body systems need attention
TrueVitals report key findings with biomarker range sliders
TrueVitals report biomarker detail for ferritin with optimal and normal ranges
TrueVitals report breakdown of every body system tested
TrueVitals clinician-reviewed summary written in plain English
Randox Health
laboratories
Clinician review
before release
Physical measurements
included
No findings,
no fee
Why Signature

The gold standard in UK blood testing. Without the £2,000 price tag.

Private hospital health assessments charge £1,000 to £2,500 and test 30 to 80 blood markers, most of them the same basic panel your GP would run. Signature tests 230, including the specialist markers those assessments send you elsewhere for, and reads every one against every other.

AssessmentBlood markersPhysical measurementsReportPrice
TrueVitals Signature230 incl. homocysteine, ApoE, ANA, anti-CCP, NGAL, IGF-1, AFP, NSE, EBVYes, read with your bloodsCross-analysed, clinician-reviewed, PhenoAge and TrueScore£799
Randox Prestige, directRandox's fullest packageYesRandox app and results with reference ranges£2,112
Private hospital "complete" assessment30 to 40YesConsultation and a results letter£1,065 to £1,199
Harley Street health screen40 to 80SometimesConsultation and lab print-out£1,500 to £2,500
Direct-to-consumer "premium" panel60 to 150 data pointsSomeDashboard with reference ranges£400 to £800
NHS Health Check3 to 4YesNumbersFree, over 40s, every 5 years

Sources, September 2026: Randox Prestige £2,112 (randoxhealth.com); Bupa Complete Health Assessment £1,199; Nuffield Health 360 Assessment around £1,065; Harley Street screening prices as publicly listed by the clinics. Marker counts from published package contents. Full premium comparison.

The obvious question

Why not go to Randox directly?

You could. Signature runs in the same Randox laboratories and the same Randox clinics. What you would not get is what happens to the results afterwards, and that is the part that turned three numbers into an answer in the case below.

Randox direct

  • Results in the Randox app, each marker against a laboratory reference range
  • You work out what connects to what
  • A GP call on some packages, not a written analysis
  • Full package from £2,112

TrueVitals Signature

  • The same Randox lab and clinic, at £799
  • Every marker read against every other and against your lifestyle, in a written report you can act on
  • Ideal ranges, not just "within the reference range"
  • PhenoAge, TrueScore and 82 calculated indices
  • A clinician reviews it before you see it
  • No findings, no fee. Full understanding guaranteed, with an account manager for life
  • Every retest compared against the last
Specialist depth

The markers you cannot get anywhere else for £799

Signature is all 140 Ultimate markers, plus 90 more that are on no other TrueVitals panel, plus six physical measurements. More than 40 of the extra 90 are specialist assays most consumer panels never run: the tests a cardiologist, rheumatologist or endocrinologist would order, together in one appointment.

Cardiovascular, beyond cholesterol Signature only

  • Homocysteine: independent heart and stroke risk, and the functional check on whether your B12 and folate are actually working. The marker customers ask for by name.
  • Apolipoprotein E: the transport protein that clears triglyceride-rich particles from the blood, a level rarely measured outside specialist lipid clinics.
  • Small dense LDL: the particle that actually clogs arteries, not just the LDL total.
  • Troponin T, CK-MB, myoglobin, FABP-3: heart muscle injury markers normally only run in A&E.
  • D-dimer: clotting activity.

Metabolic, before HbA1c moves Signature only

  • Adiponectin: the fat-cell hormone that falls years before insulin resistance shows on standard tests.
  • Fructosamine: a two to three week glucose average that catches what a three-month HbA1c smooths over.
  • NEFA: free fatty acids, the fuel of metabolic dysfunction.

Autoimmune, as a rheumatologist would Signature only

  • ANA and anti-CCP: lupus and rheumatoid arthritis, years before joint damage.
  • Intrinsic factor and gastric parietal cell antibodies: pernicious anaemia, the autoimmune cause of B12 deficiency.
  • Complement C3 and C4: whether your immune system is quietly active.

Tumour markers beyond the basic five Signature only

  • AFP (liver), NSE (neuroendocrine and small-cell lung), hCG (testicular and germ cell), mesothelin (mesothelioma and ovarian), alongside CEA, CA 19-9, PSA, CA 125 and CA 15-3.
  • Screening support read in context, never a diagnosis on their own.

Kidney damage before eGFR drops Signature only

  • NGAL: acute kidney injury, in hours rather than months.
  • Beta-2-microglobulin: tubular damage and haematological screening.
  • Microalbumin/creatinine ratio: the earliest sign of diabetic kidney damage.

Nutritional depth Signature only

  • Active B12: the fraction your cells can actually use.
  • Red cell folate: months of folate status, not last week's meals.
  • Zinc, copper, total antioxidant status, glutathione reductase (riboflavin).

Endocrine and bone Signature only

  • IGF-1: the growth hormone axis, ageing and body composition.
  • Calcitonin: medullary thyroid cancer screen. TBG.
  • DKK-1: bone formation, rarely available outside research.

Digestive and viral Signature only

  • H. pylori and gastrin: stomach ulcer and stomach cancer risk.
  • Epstein-Barr, three antibodies: settles whether unexplained fatigue is post-viral.

Inflammation at cytokine level Signature only

  • Interleukins 5, 8, 15, 17A, 17F and 22, EGF, HB-EGF, MCP-1, GM-CSF: the signalling molecules behind chronic inflammation.
  • Haptoglobin, ASO: haemolysis and recent streptococcal infection.

All of the above are delivered today. A small number of specification markers are currently unavailable from the laboratory and are listed plainly further down.

A real Signature report

Years of unexplained symptoms. Three markers that connected them.

A man in his thirties came to Signature after years of investigations elsewhere. Fatigue, bloating, and strong reactions to certain foods, including an onion-like smell through his skin and sweat after eating them. Every standard test had been normal.

His standard markers were excellent. Metabolic health among the best we have reported, a clean liver, healthy hormones, negative coeliac and H. pylori screens, and hs-CRP so low it ruled out systemic inflammation. On an ordinary panel the story would have ended there: nothing to see.

The specialist markers told a different story. Glutathione reductase came back more than double its threshold, a severe riboflavin (B2) deficiency. B2 is the cofactor that recycles glutathione, the body's master antioxidant and the molecule the liver uses to process sulphur compounds. Without it, sulphur that should leave through the liver looks for another way out, including the skin. For the first time there was a biochemical explanation for the symptom no one had been able to name.

Two more findings changed the plan. Gastrin, the hormone that drives stomach acid, was below range, which explained the bloating and why protein-rich foods fermented into exactly the compounds he could not tolerate. And haptoglobin was critically low, a sign that red cells were being broken down faster than normal, something his healthy haemoglobin had been quietly masking. That one went straight to his GP with the specific follow-up tests named.

The report gave him three things: a mechanism for a symptom he had lived with for years, a supplement to start that week, and a precise handover for his GP. None of the three markers is on any other TrueVitals panel, or on most consumer panels at any price.

Signature only

Glutathione reductase

The functional test for riboflavin. His was 71 against a threshold of 33: the missing link in how his body handles sulphur.

Signature only

Gastrin

Below range. Low stomach acid, undigested protein, and the bacterial by-products behind the bloating.

Signature only

Haptoglobin

Critically low, pointing to red cell breakdown a normal haemoglobin had hidden. Flagged for GP investigation with the exact tests to request.

Absolutely excellent life changing results.
Signature customerVerified on TrustpilotSeptember 2026

Shared with the customer's permission, on the condition that he stays anonymous. Identifying details and medical history have been withheld. Results are informational and supported, not replaced, the care of his GP.

Two numbers

Your biological age. Your score out of 100.

Two hundred and thirty results are a lot to hold in your head. Every Signature report resolves them into two numbers you can track from one test to the next.

PhenoAge

Your biological age, from your blood

A validated biological age (Levine et al., 2018) calculated from nine of your markers and your actual age. Younger than your birthday is good. Older is the clearest reason to act, and the number to bring down on your next test.

TrueScore/100

The whole report in one figure

Every system scored, then capped by the most serious finding, so nothing important can be averaged away. One number to track, and a report that tells you exactly what moved it.

Signature exclusive

More than a blood test

Six measurements taken at your appointment and read alongside your biomarkers: blood pressure, waist, hip, height, weight and resting pulse. They feed eleven body-composition indices in your report, from BMI and waist-to-hip ratio to estimated lean and fat mass.

Two guarantees

The same guarantees as Ultimate, on 230 markers

01

No findings, no fee

If nothing across all 230 markers and six measurements comes back outside the ideal range, we refund the full panel price. Either you get complete peace of mind for free, or you find something worth acting on while there's time to act on it.

02

Full understanding guaranteed

A dedicated account manager for life. Any question about any marker on your report, answered. At this depth there will be results you have never seen before, and you should never have to Google one.

Full biomarker list

Search all 230 biomarkers

Type any marker to check it is included, or browse by system.

230 biomarkers for men · 229 for women
Markers currently unavailable from the laboratory▼
A number of markers on the Signature specification are not being processed by Randox at present. This is a Randox-wide issue, not specific to TrueVitals, and they will be added to reports as soon as processing resumes. They are not counted in the delivered list above.
  • Extended interleukins: IL-1a, 1B, 2, 3, 4, 6, 7, 10, 12p70, 13, 23, and soluble receptors sIL-2Ra, sIL-6R, sTNFRI, sTNFRII
  • Growth factors and adhesion molecules: TNF-alpha, VEGF, MIP-1a, MMP-9, amphiregulin, TGF-alpha, PD-1, E/L/P-selectin, ICAM-1, VCAM-1
  • Tissue and neurological: FABP-4 to FABP-9, GFAP, NDKA, PARK7, GSTpi
  • Cytokine autoantibody profile: 20 tests
  • Digestive: pepsinogen I, II, ratio and gastrin-17
  • Kidney and metabolic: urinary cystatin C, urinary NGAL, KIM-1, leptin, resistin, apolipoprotein CII and CIII
  • Prostate: free PSA and nicked PSA (men)
Who it's for

Signature is for you if

You were about to pay a private hospital £1,000 or more for an assessment, and would rather have five times the blood markers for £799.

There is cancer, autoimmune or heart disease in your family and you want all three screened properly, once, in one appointment.

Standard tests keep coming back normal and you want somewhere for the answer to show up.

You treat your health data like your financial data: comprehensively, annually, without gaps.

Most people should start with Ultimate at £349. Signature is the step beyond it, for when you want nothing left unchecked.

The process

From order to report

1

Order, then book

Randox emails a secure booking link, usually within a working hour. Choose from 60+ Randox Health clinics across the UK and Ireland.

2

Full assessment

Venous blood, urine and physical measurements at the clinic. Around 30 minutes. Fast from 10pm the night before.

3

Randox lab analysis

Every marker processed through Randox Health's own laboratory network and courier system.

4

Your report

Every marker read against every other, PhenoAge and TrueScore calculated, a clinician reviews it, and it lands within 12 working days of your appointment.

FAQs

Signature Panel FAQs

Yes. £799 covers the panel, Randox laboratory processing, your clinic appointment including physical measurements, PhenoAge, TrueScore and your clinician-reviewed report. Nothing else to pay. Appointments are at Randox Health clinics; there are no home visits for Signature.

Yes. If nothing on your report is flagged as outside the ideal range, across every marker and measurement, we refund the full panel price. Ideal ranges are narrower than laboratory reference ranges, so this is a high bar, which is the point. Full terms.

Signature includes all 140 Ultimate markers and adds 90 specialist ones: homocysteine, ApoE, small dense LDL, cardiac injury markers, adiponectin and fructosamine, ANA and anti-CCP, NGAL, IGF-1, calcitonin, active B12 and red cell folate, four extra tumour markers, H. pylori, Epstein-Barr and the cytokines. It adds physical measurements, and it is processed by Randox Health rather than our UKAS partner laboratory. Signature is Ultimate's 140 plus 90, not a different test. Both include PhenoAge, TrueScore, clinician review and the guarantees.

Yes. Choose Klarna or Clearpay at checkout. Klarna splits it into three interest-free payments of £266.33, a month apart.

Use the search above. Type any marker name to see whether it is on the panel and which system it sits in.

At any Randox Health clinic. After purchase Randox emails a secure booking link, usually within one working hour, to choose your clinic and time. Use the map on this page to find your nearest.

Your report is delivered within 12 working days of your appointment, as a written report, downloadable PDF and interactive dashboard.

No. They can be raised or normal for reasons unrelated to cancer. They are screening support, read in the context of everything else on the report, and anything of concern is flagged for follow-up with your GP.

Some markers, including the cytokines and DKK-1, sit at the frontier of clinical screening and are rarely available outside research. They are reported with context, not as diagnostics.

Yes. Total PSA and the prostate risk score for men; CA 125, CA 15-3 and prolactin recovery for women. That gives 230 for men and 229 for women.

Signature clinics

Your appointment is at a Randox Health clinic

Search your postcode to see the nearest of the 60+ Randox Health venues across the UK and Ireland. Randox books your appointment with you after purchase.

The gold standard

230 biomarkers. Physical measurements. PhenoAge and TrueScore. One appointment.

Processed by Randox Health, read across every system and reviewed by a clinician before release. Guaranteed.

£799
Clinic appointment included
Klarna3 interest-free payments of £266.33

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Who chooses Signature, and why

230 biomarkers processed by Randox, collected at a Randox clinic with physical measurements on the day. These guides explain when that depth earns its price, and how it compares to what else is on the market.