Specialist marker · Heart and lipids
An apolipoprotein E (ApoE) blood test measures the level of ApoE protein that helps clear fats from your blood. It is not the APOE gene test linked to Alzheimer's risk; that is a separate genetic test. ApoE levels are included in TrueVitals Signature (£799), read alongside ApoB, ApoA-1, Lp(a) and small dense LDL.
ApoE is a protein on several types of lipid particle, including the remnants left after triglyceride-rich particles have delivered their fat. It acts as a key that lets the liver recognise and clear those particles from the blood.
When ApoE is not doing its job well, cholesterol-rich remnants linger in the blood, which is linked to plaque build-up.
ApoE is reported in mg/dL against the lab's reference range. Raised levels often travel with high triglycerides and remnant cholesterol. Your report reads ApoE alongside your full lipid profile rather than on its own.
| Option | Includes it | Price | What else you get |
|---|---|---|---|
| TrueVitals Signature | Yes | £799 incl. draw | With ApoB, ApoA-1, Lp(a), small dense LDL, homocysteine and the rest of Signature's 45 specialist markers. Up to 12 working days. |
| TrueVitals Ultimate | No | £399 | Not included. Ultimate has ApoB, ApoA-1, Lp(a) and remnant cholesterol. |
| NHS GP | No | Not usually offered | Rarely measured outside specialist lipid clinics. |
TrueVitals prices checked 5 November 2026. Every TrueVitals report is clinician-reviewed. Pay in instalments with Klarna or Clearpay. Signature is drawn at one of 70 Randox Health clinics; Ultimate at one of 103 partner clinics or with a home visit.
If you want your Alzheimer's risk gene: this is not that test. Genetic results can be hard to live with, so consider genetic counselling before an APOE genotype test.
A private panel is a good way to get a baseline, understand a result in context and track it over time. It does not replace your GP for symptoms, and anything that needs follow-up is flagged in plain words in your report.
ApoE on its own rarely tells the whole story. In TrueVitals panels it is reported with these related markers:
No. This measures the amount of ApoE protein in your blood. The APOE4 test is a genetic test for which version of the gene you carry.
No. ApoE is included in Signature. Ultimate covers ApoB, ApoA-1, Lp(a) and remnant cholesterol.
It often travels with high triglycerides and remnant cholesterol, suggesting fat-carrying particles are not being cleared efficiently. Your report reads it with your other lipids.
Yes, fasting is advised, as triglyceride-related markers are clearer after an overnight fast.
How this page was written: by James Smillie, founder of TrueVitals, reviewed by the TrueVitals clinical review team, using NHS and laboratory reference sources. Ranges are typical values; your report uses your lab's own ranges. TrueVitals sells the panels named on this page, so we have stated plainly what this test cannot do. Last updated 5 November 2026.
Signature: 230 biomarkers including all 45 specialist markers: ApoE, small dense LDL, homocysteine and more. £799 including the draw.
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